Product Details
| Alternative Name: | B-cell lymphoma 6 protein, B-cell lymphoma 5 protein, Bcl5 |
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| Clone: | SPM602 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Recombinant human Bcl6. |
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| UniProt ID: | P41182 |
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| Species reactivity: | Human, Mouse
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| Specificity: | Recognizes a protein of 95kDa, which is identified as Bcl-6. |
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| Applications: | IHC
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. |
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| Regulatory Status: | RUO - Research Use Only |
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IHC testing of formalin-fixed, paraffin-embedded human tonsil stained with anti-Bcl6 antibody
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Product Literature References
The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection: G.J. Nuovo, et al.; Ann. Diagn. Pathol.
61, 152057 (2022),
Abstract;
