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Bcl6 monoclonal antibody (SPM602)

 
ENZ-ABS771-0100 100 µg 708.00 USD
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Product Details

Alternative Name:B-cell lymphoma 6 protein, B-cell lymphoma 5 protein, Bcl5
 
Clone:SPM602
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Recombinant human Bcl6.
 
UniProt ID:P41182
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes a protein of 95kDa, which is identified as Bcl-6.
 
Applications:IHC
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
 
Regulatory Status:RUO - Research Use Only
 
Bcl6 monoclonal antibody (SPM602) IHC
IHC testing of formalin-fixed, paraffin-embedded human tonsil stained with anti-Bcl6 antibody
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Bcl6 monoclonal antibody (SPM602) IHC

Product Literature References

The amplification of CNS damage in Alzheimer's disease due to SARS-CoV2 infection: G.J. Nuovo, et al.; Ann. Diagn. Pathol. 61, 152057 (2022), Abstract;

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