| Alternative Name: | Inhibitor of nuclear factor κ-B kinase subunit beta, IκB kinase β, IKK2, NF-κB inhibitor kinase β |
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| Clone: | IKB355 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Recombinant protein fragment of IKK β. |
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| UniProt ID: | O14920 |
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| Species reactivity: | Human, Mouse
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| Applications: | WB
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | NF-κB is sequestered in the cytoplasm by IκBα, unable to translocate to the nucleus. IκB is part of the canonical pathway for NF-κB activation. IKKβ is part of the IκB kinase complex, along with a second catalytic subunit, IKKα, and a regulatory subunit, IKKγ. Along with IKKα, IKKβ phosphorylates IκBα leading to its degradation and release of inhibition of NF-κB. The RELA subunit of active NF-κB is then free to enter the nucleus and initiate a number of signaling cascades. |
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| Regulatory Status: | RUO - Research Use Only |
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