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Transglutaminase 2 monoclonal antibody (419)

ENZ-ABS764-0100 100 µg 723.00 USD
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Product Details

Alternative Name:Tissue transglutaminase, TGase 2, Protein-glutamine γ-glutamyltransferase
Immunogen:Recombinant full-length human protein was used as the immunogen for the Transglutaminase 2 antibody.
UniProt ID:P21980
Species reactivity:Human
Specificity:Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II).
Purity Detail:Protein G affinity purified
Formulation:Liquid. In 1X PBS containing 0.1 mg/ml BSA and 0.05% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Regulatory Status:RUO - Research Use Only
Transglutaminase 2 monoclonal antibody (419) IHC tonsil
IHC Formalin-fixed, paraffin-embedded human tonsil stained with Transglutaminase 2 antibody 
Transglutaminase 2 monoclonal antibody (419) IHC placenta
IHC Formalin-fixed, paraffin-embedded human placenta stained with Transglutaminase 2 antibody.
Transglutaminase 2 monoclonal antibody (419) SDS-PAGE
SDS-PAGE Analysis of Purified Transglutaminase 2 Antibody
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Transglutaminase 2 monoclonal antibody (419) IHC tonsil Transglutaminase 2 monoclonal antibody (419) IHC placenta Transglutaminase 2 monoclonal antibody (419) SDS-PAGE

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