| ENZ-ABS739-0100 | 100 µl | 477.00 USD |  |
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| Alternative Name: | Protein phosphatase 1A (formerly 2C) magnesium-dependent α isoform, PDP1 |
| Clone: | p6C7 |
| Host: | Mouse |
| Isotype: | IgG2bκ |
| Immunogen: | Recombinant human PP2Cα/PPM1A (aa 1-382) purified from E. coli. |
| UniProt ID: | P35813 |
| Source: | Purified from hybridoma tissue culture supernatant. |
| Species reactivity: | Human |
| Applications: | ELISA, ICC, IF, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:500-1:2,000). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified |
| Formulation: | Liquid. In PBS, pH 7.4, containing 0.02% sodium azide and 10% glycerol. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Protein phosphatase 2C (PP2Calpha) is a Mn2+ - or Mg2+-dependent protein serine/threonine phosphatase that inhibits the human stress-responsive p38 and JNK MAPK pathways and regulates cellular stress response in eukaryotes. The PPM (metal-dependent protein phosphatase) family of Ser/Thr protein phosphatases have recently been shown to down-regulate the stress response pathways in eukaryotes. Within the stress pathway, key signaling_x000D_ kinases, which are activated by protein phosphorylation, have been proposed as the in vivo substrates of PP2Cα, the prototypical member of the PPM family. |
| Regulatory Status: | RUO - Research Use Only |
