| Alternative Name: | Natural cytotoxicity triggering receptor 1 isoform a, NCR1, CD335 |
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| Clone: | n1D9 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Recombinant human Nkp46/NCR1 (aa 22-255) purified from E. coli. |
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| UniProt ID: | O76036 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human
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| Applications: | ELISA, Flow Cytometry
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| Formulation: | Liquid. In PBS, pH 7.4, containing 0.02% sodium azide and 10% glycerol. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. |
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| Regulatory Status: | RUO - Research Use Only |
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