| Alternative Name: | Natural cytotoxicity triggering receptor 1 isoform a, NCR1, CD335 |
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| Clone: | n1D9 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Recombinant human Nkp46 (aa 22-255) purified from E. coli. |
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| UniProt ID: | O76036 |
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| Source: | Purified from ascites. |
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| Species reactivity: | Human
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| Applications: | ELISA, Flow Cytometry
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| Purity Detail: | Protein G affinity purified |
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| Formulation: | Liquid. In PBS, pH 7.4, containing 0.02% sodium azide and 10% glycerol. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. |
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| Regulatory Status: | RUO - Research Use Only |
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Flow cytometry analysis of NKp46/NCR1 in PBMC. The cell was stained at 2-5 µg for
1x106 cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (darkgray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).
Flow cytometry analysis of NKp46/NCR1 in HeLa cells. The cell was stained at
2-5 µg for 1x106 cells (red). A Goat anti mouse IgG (Alexa Fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).
