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LIGHT monoclonal antibody (7B9E12)

ENZ-ABS699-0100 100 µg 560.00 USD
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Product Details

Alternative Name:TNFSF14, CD258, HVEML
Immunogen:Extracellular domain of human LIGHT.
UniProt ID:O43557
Species reactivity:Human
Applications:Flow Cytometry, ICC, IF, IHC (PS), WB
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells, LIGHT binding to LTβR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction. LIGHT may become a potent tool in anti-cancer treatment.
Regulatory Status:RUO - Research Use Only
LIGHT monoclonal antibody (7B9E12) WB
Western blot analysis of LIGHT in overexpressing HEK293 cells with LIGHT antibody at 0.5 and 1 µg/ml
LIGHT monoclonal antibody (7B9E12) IHC
Immunohistochemistry of LIGHT in human lymphoma tissue with LIGHT antibody at 5 µg/mL.
LIGHT monoclonal antibody (7B9E12) IF
Immunofluorescence of LIGHT in transfected HEK293 cells with LIGHT antibody at 2 µg/mL. Green: LIGHT Antibody [7B9E12] Blue: DAPI staining
LIGHT monoclonal antibody (7B9E12) FACS
Flow cytometry analysis of LIGHT overexpressing HEK293 cells using LIGHT antibody and control mouse IgG antibody at 10 µg/ml. Blue: Untransfected HEK293 cells. Yellow: LIGHT overexpressing HEK293 cells.
LIGHT monoclonal antibody (7B9E12) ICC
Immunocytochemistry of LIGHT in transfected HEK293 cells with LIGHT antibody at 1 µg/mL. Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 1 µg/mL.
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LIGHT monoclonal antibody (7B9E12) WB LIGHT monoclonal antibody (7B9E12) IHC LIGHT monoclonal antibody (7B9E12) IF LIGHT monoclonal antibody (7B9E12) FACS LIGHT monoclonal antibody (7B9E12) ICC

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