| Alternative Name: | CD273, PDCD1L2, Programmed cell death 1 ligand 2, PD-1 ligand 2 |
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| Clone: | 7C7 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Extracellular domain of human PD-L2. |
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| UniProt ID: | P9BQ51 |
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| Species reactivity: | Human
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| Applications: | Flow Cytometry, ICC, IF, IHC (PS), WB
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC).T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. |
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| Regulatory Status: | RUO - Research Use Only |
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Western blot analysis of PD-L2 in overexpressing HEK293 cells PD-L2 antibody at 0.5 and 1 µg/ml
Immunohistochemistry of PD-L2 in human tonsil tissue with PD-L2 antibody at 2 µg/mL.
Immunofluorescence of PD-L2 in transfected HEK293 cells with PD-L2 antibody at 20 µg/mL. Green: PDL2 Antibody [7C7] Blue: DAPI staining
Immunocytochemistry of PD-L2 in transfected HEK293 cells with PD-L2 antibody at 5 ug/mL. Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 5 ug/mL.
