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PDI monoclonal antibody (1D3)

ENZ-ABS686-0050 50 µg 296.00 USD
ENZ-ABS686-0200 200 µg 646.00 USD
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Product Details

Alternative Name:P4HB, Protein disulfide isomerase
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI.
UniProt ID:P04785
Source:Purified from hybridoma tissue culture supernatant.
Species reactivity:Human, Mouse, Rat
Bovine, Chicken, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus
Applications:ICC, IF, IHC, WB
Electron microscopy
Recommended Dilutions/Conditions:Immunohistochemistry (1:200-1:500)
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~58kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.
Regulatory Status:RUO - Research Use Only
PDI monoclonal antibody (1D3) WB
Western Blot analysis of ENZ-ABS686: Lane 1: MW marker, Lane 2: 3T3 (heat shocked), (cell lysate) (Prod. No. ADI-LYC-3T101), Lane 3: PC-12 (heat shocked), (cell lysate) (Prod. No. ADI-LYC-PC101), Lane 4: HeLa (heat shocked), (cell lysate) (Prod. No. ADI-LYC-HL101), Lane 5: Vero (heat shocked) cell lysate.
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PDI monoclonal antibody (1D3) WB

Product Literature References

African swine fever virus transmembrane protein pEP84R guides core assembly: A. Alejo, et al.; PLoS Pathog. 19, e1011136 (2023), Abstract;
Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcemia: B.H. Mullin, et al.; J. Endocr. Soc. 6, bvac025 (2022), Abstract;
Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease: S. Stricker, et al.; Int. J. Mol. Sci. 23, 2248 (2022), Abstract;

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