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HO-1 monoclonal antibody (HO-1-1)

ENZ-ABS663-0050 50 µg 321.00 USD
ENZ-ABS663-0200 200 µg 586.00 USD
ENZ-ABS663-1000 1 mg 2,342.00 USD

Product Details

Alternative Name:HMOX1, Hsp32, Heat shock protein 32, Heme oxygenase 1
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human HO-1.
UniProt ID:P09601
Source:Purified from hybridoma tissue culture supernatant.
Species reactivity:Human, Mouse, Rat
Bovine, Dog
Applications:Flow Cytometry, ICC, IHC (PS), WB
Recommended Dilutions/Conditions:Flow Cytometry (10µg/ml)
Western Blot (1:1,000 ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
Regulatory Status:RUO - Research Use Only
HO-1 monoclonal antibody (HO-1-1) WB
Western Blot analysis of ENZ-ABS663: Lane 1: MW Marker, Lane 2: HO-1 (rat), (recombinant) (Prod. No. ADI-SPP-730), Lane 3: HO-1 (human), (recombinant) (Prod. No. ADI-SPP-732), Lane 4: HO-2 (human), (recombinant) (Prod. No. ADI-SPP-550), Lane 5: MDBK cell lysate.
HO-1 monoclonal antibody (HO-1-1) FACS
Flow cytometry analysis of 106 Jurkat cells stained using HO-1 monoclonal antibody (HO-1-1), (Prod. No. ENZ-ABS663) conjugated to FITC, at a concentration of 10µg/ml.
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HO-1 monoclonal antibody (HO-1-1) WB HO-1 monoclonal antibody (HO-1-1) FACS

Product Literature References

Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages: L. An, et al.; J. Leukoc. Biol. 112, 437 (2022), Abstract;
GM-CSF-mediated inducement of bone marrow MDSCs by TSA and effect on survival of graft in mice: S. Zhao, et al.; Eur. J. Med. Res. 27, 161 (2022), Abstract;

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Heme oxygenase 1
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