| Alternative Name: | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, IL-2-RA, TAC antigen, p55 |
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| Clone: | Basiliximab |
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| Host: | Rabbit |
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| Isotype: | IgGκ |
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| Immunogen: | Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells. |
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| UniProt ID: | P01589 |
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| Species reactivity: | Human
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| Specificity: | Recognizes human IL-2R and binds to the epitope E116RIYHFV122 within the extracellular domain of the CD25 subunit. Binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (αβγc) – T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation. |
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| Applications: | Flow Cytometry, IF, IHC, WB, FUNC
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% Proclin 300. |
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| Use/Stability: | Stable at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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| Regulatory Status: | RUO - Research Use Only |
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