| Alternative Name: | Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Tyrosine kinase-type cell surface receptor HER2, CD340 |
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| Clone: | 4D5-8 (Trastuzumab) |
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| Host: | Rabbit |
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| Isotype: | IgGκ |
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| Immunogen: | A431 cells (human epidermoid carcinoma) (over)expressing EGFR. |
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| UniProt ID: | P04626 |
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| Species reactivity: | Human
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| Applications: | ELISA, Flow Cytometry, IHC
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% Proclin 300. |
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| Use/Stability: | Stable at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder. |
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| Technical Info/Product Notes: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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| Regulatory Status: | RUO - Research Use Only |
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