| Alternative Name: | CD299, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, DC-SIGN-related protein, CLEC4M, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, DC-SIGN2, Liver/lymph node-specific ICAM-3-grabbing non-integrin, L-SIGN |
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| Clone: | 16E7 |
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| Host: | Rabbit |
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| Isotype: | IgGκ |
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| Immunogen: | CD299 |
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| UniProt ID: | Q9H2X3 |
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| Species reactivity: | Human
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| Applications: | Flow Cytometry, IHC
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% Proclin 300. |
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| Use/Stability: | Stable at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection. |
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| Technical Info/Product Notes: | This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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| Regulatory Status: | RUO - Research Use Only |
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