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TROP2 (human) monoclonal antibody (01)

ENZ-ABS380-0100 100 µl 305.00 USD
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Product Details

Alternative Name:Tumor associated calcium signal transducer 2, GA733-1, M1S1, TACSTD2
Immunogen:Recombinant human TROP2 extracellular domain.
UniProt ID:P09758
Species reactivity:Human
Crossreactivity:Does not cross-react with mouse or rat TROP2.
Applications:ELISA, Flow Cytometry, IHC (PS)
Purity Detail:Protein A affinity purified.
Formulation:Liquid. 0.2 µM filtered solution in PBS.
Handling:Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%) It is toxic to cells and should be disposed of properly. Avoid freeze-thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells. Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis. Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.
Regulatory Status:RUO - Research Use Only

Product Literature References

Biomarker Analyses in the Phase 3 ASCENT Study of Sacituzumab Govitecan Versus Chemotherapy in Patients with Metastatic Triple-Negative Breast Cancer: A. Bardia, et al.; Ann. Oncol. 32, 1148 (2021), Abstract;

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