| ENZ-ABS370-0100 | 100 µg | 466.00 USD |  |
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| Alternative Name: | Homeobox protein Nkx-2.2 |
| Clone: | NX2/1422R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant human NKX2.2 protein fragment. |
| UniProt ID: | O95096 |
| Gene/Protein Identifier: | 4821 (Gene ID) |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IF, IHC (PS) |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL) Immunofluorescence (1-2 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL for 30 minutes at RT) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | NKX2.2 acts as a transcriptional activator. Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. |
| Regulatory Status: | RUO - Research Use Only |
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