| ENZ-ABS336-0100 | 100 µg | 554.00 USD |  |
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| Alternative Name: | CAD, CDM |
| Clone: | RMCDN1-1 |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant full length human Caldesmon. |
| UniProt ID: | Q05682 |
| Species reactivity: | Human |
| Applications: | IF, IHC (PS) |
| Recommended Dilutions/Conditions: | Immunofluorescence (0.5-1 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL for 30 min at RT) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Caldesmon is an actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. |
| Regulatory Status: | RUO - Research Use Only |
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