| ENZ-ABS325-0100 | 100 µg | 554.00 USD |  |
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| Alternative Name: | Discovered on gastrointestinal stromal tumors protein 1, ANO1, Anoctamin-1, TMEM16A, Transmembrane protein 16A |
| Clone: | DG1/1487R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant full length human DOG1. |
| UniProt ID: | Q5XXA6 |
| Gene/Protein Identifier: | 55107 (Gene ID) |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IF, IHC (PS) |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL) Immunofluorescence (0.5-1 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL) for 30 minutes at RT Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 % of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including platelet-derived growth factor Receptor α mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%. |
| Regulatory Status: | RUO - Research Use Only |
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