| ENZ-ABS323-0100 | 100 µg | 592.00 USD |  |
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| Alternative Name: | T-cell surface glycoprotein CD8 (α chain), T-lymphocyted differentiation antigen T8/Leu-2 |
| Clone: | C8/1779R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant full length human CD8a. |
| UniProt ID: | P01732 |
| Species reactivity: | Human |
| Applications: | Flow Cytometry, IF, IHC (PS) |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells Immunofluorescence (0.5-1 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL for 30 min at RT) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. |
| Regulatory Status: | RUO - Research Use Only |
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