| Alternative Name: | Adrenocorticotropic hormone, Corticotropin |
| |
| Clone: | r57 |
| |
| Host: | Mouse |
| |
| Isotype: | lgG1 |
| |
| Immunogen: | An N-terminal peptide (within aa 1-24) from the Synacthen/ACTH region of human POMC. |
| |
| UniProt ID: | P01189 |
| |
| Species reactivity: | Human, Mouse, Rat
|
| |
| Specificity: | This mAb is specific to Synacthen (aa 1-24 of ACTH); does not cross-react with CLIP (aa 17-39 of ACTH). |
| |
| Applications: | IHC (PS)
|
| |
| Recommended Dilutions/Conditions: | Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL) for 30 minutes at RT
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
| |
| Purity Detail: | Protein G affinity purified. |
| |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| |
| Shipping: | Shipped on Blue Ice |
| |
| Long Term Storage: | +4°C |
| |
| Scientific Background: | ACTH (adrenocorticotropic hormone, corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, α-MSH (melanocyte stimulating hormone), β-MSH, γ-MSH, CLIP (corticotropin-like intermediary peptide), lipotropin-β, lipotropin-γ, β-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
