| Alternative Name: | Cystic fibrosis transmembrane conductance regulator, ABCC7 |
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| Clone: | CFTR/1775R |
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| Host: | Rabbit |
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| Isotype: | IgGκ |
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| Immunogen: | Recombinant human CFTR (aa 258-385). |
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| UniProt ID: | P13569 |
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| Gene/Protein Identifier: | 1080 (Gene ID) |
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| Species reactivity: | Human
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| Applications: | IF, IHC (PS)
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| Recommended Dilutions/Conditions: | Immunofluorescence (0.5-1 µg/mL)
Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL for 30 min at RT)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein A affinity purified. |
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| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | +4°C |
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| Scientific Background: | CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. |
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| Regulatory Status: | RUO - Research Use Only |
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