| Alternative Name: | Histone-binding protein RBBP7, Retinoblastoma-binding protein 7, RBBP-7, Retinoblastoma-binding protein p46, Histone acetyltransferase type B subunit |
| |
| Host: | Rabbit |
| |
| Isotype: | IgG |
| |
| Immunogen: | Synthetic peptide corresponding to aa 1-13 (MASKEMFEDTVEEC) of human RbAp46. |
| |
| UniProt ID: | Q16576 |
| |
| Species reactivity: | Human
|
| |
| Specificity: | Recognizes human RbAp46. |
| |
| Applications: | ICC, IF, IHC, WB
|
| |
| Application Notes: | Detects a band of ~46kDa by Western blot. |
| |
| Purity Detail: | Antigen affinity chromatography |
| |
| Formulation: | Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide. |
| |
| Handling: | Avoid freeze/thaw cycles. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Scientific Background: | RbAp46 is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp46 shares about 75% sequence identity with the closely related RbAp48, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp46 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
