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RbAp46 polyclonal antibody (biotin conjugate)

 
ENZ-ABS285-0100 100 µg 327.00 USD
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Product Specification

Alternative Name:Histone-binding protein RBBP7, Retinoblastoma-binding protein 7, RBBP-7, Retinoblastoma-binding protein p46, Histone acetyltransferase type B subunit
 
Host:Rabbit
 
Isotype:IgG
 
Immunogen:Synthetic peptide corresponding to aa 1-13 (MASKEMFEDTVEEC) of human RbAp46.
 
UniProt ID:Q16576
 
Species reactivity:Human
 
Specificity:Recognizes human RbAp46.
 
Applications:ICC, IF, IHC, WB
 
Application Notes:Detects a band of ~46kDa by Western blot.
 
Purity Detail:Antigen affinity chromatography
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:RbAp46 is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp46 shares about 75% sequence identity with the closely related RbAp48, and appears to be functionally related to the yeast MSI1 protein in that overexpression of RbAp46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp46 has also been demonstrated to be up-regulated by the Wilms’ tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth.
 
Regulatory Status:RUO - Research Use Only
 

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