| Alternative Name: | Prohormone convertase 1, Neuroendocrine convertase 1, NEC 1, Proprotein convertase 1 |
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| Host: | Rabbit |
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| Isotype: | IgG |
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| Immunogen: | Synthetic peptide corresponding to aa 111-127 (VQKDSALDLFNDPMWN) of mouse PC1. |
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| UniProt ID: | P63239 |
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| Species reactivity: | Mouse
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| Applications: | WB
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| Application Notes: | Detects a band of ~80kDa by Western blot. |
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| Purity Detail: | Antigen affinity chromatography |
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| Formulation: | Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The PC family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm. |
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| Regulatory Status: | RUO - Research Use Only |
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