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XBP-1S monoclonal antibody (8F6.11)

ENZ-ABS255-0100 100 µg 501.00 USD
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Product Details

Alternative Name:X-box binding protein 1, Tax-responsive element-binding protein 5, TREB5, XBP2
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human XBP-1, spliced isoform XBP1(S).
UniProt ID:P17861
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Human, Mouse
Applications:ELISA, ICC, IP, WB
Recommended Dilutions/Conditions:Immunocytochemistry (1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~60kDa by Western blot.
Purity Detail:Protein G affinity purified.
Formulation:Liquid. In PBS containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). XBP-1 mRNA is spliced by IRE1p under ER stress, resulting in a 371 amino acid protein (XBP-1s) which is translocated to the nucleus where it binds to the regulatory elements of downstream genes. XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones grp78 and grp94.
Regulatory Status:RUO - Research Use Only
XBP-1S monoclonal antibody (8F6.11) Western blot
Western blot analysis of XBP-1S mAb (8F6.11) (Prod. No. ENZ-ABS255): Lane 1: MW markers, Lane 2: mock-transfected CHO cell, Lane 3: XBP-1S (spliced isoform)-transfected CHO cell. The observed molecular weight of XBP-1S is ~60 kDa (calculated MW: 40 kDa).
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XBP-1S monoclonal antibody (8F6.11) Western blot

Product Literature References

Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57: S. Piacentini, et al.; Sci. Rep. 8, 10425 (2018), Abstract; Full Text

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