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APP polyclonal antibody

ENZ-ABS226-0100 100 µg 445.00 USD
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Product Details

Alternative Name:Amyloid A4 protein, Amyloid protein, ABPP, APPI, Amyloid beta A4 protein
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human APP.
UniProt ID:P05067
Source:Purified from rabbit serum.
Species reactivity:Human, Mouse
Applications:ELISA, IP, WB
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Deposition of APP (Amyloid A4 protein) precursor intraneuronally as neurofibrillary tangles, extracellularly as plaques, and in blood vessels, is characteristic of both Alzheimer's disease and aged Down's Syndrome. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770. They are produced by alternative splicing of the APP gene. APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere.
Regulatory Status:RUO - Research Use Only
APP polyclonal antibody Western blot
HEK cells were transfected with pCDNA3-APP695 (lane 2), pCDNA3-APP695 ΔC31 (lane 3) or pCDNA3 (lane 4) constructs. 10µg of total cell lysates were separated by 7.5% SDS-PAGE for Western Blot. The membrane was immunoblotted with primary antibody (ENZ-ABS226, APP, pAb) at 1:1000 dilution. Anti-rabbit IgG-AP (Prod. No. ADI-SAB-301) was used at 1:4000 dilution. The result showed this antibody detected both full length APP695 and APP695 ΔC31 at about 98 KDa. Pre-stained protein marker is shown in lane 1.
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APP polyclonal antibody Western blot