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DIBAC4(3) (ultra pure)

Membrane Potential Detector
ENZ-52205 25 mg 204.00 USD
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DiBAC4(3) is a sensitive slow-response probe for measuring cellular membrane potential. In general, slow-response probes exhibit potential-dependent changes in their transmembrane distribution that are accompanied by a fluorescence change. The magnitude of response is much larger than fast-response probes. Slow-response probes, which include cationic carbocyanines, rhodamines and anionic oxonols, are suitable for detecting changes in average membrane potentials of nonexcitable cells caused by respiratory activity, ion-channel permeability, drug binding and other factors. DiBAC4(3) has been employed in flow cytometry to monitor antibacterial activity of defensins. Wavelength Maxima: Excitation 493nm, Emission 516nm

Product Details

Alternative Name:bis-(1,3-Dibarbituric acid)-trimethine oxonol
Purity:≥98% (HPLC)
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least one year after receipt when stored as recommended.
Handling:Protect from light. Keep cool and dry.
Technical Info/Product Notes:This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization: T. Ziglari, et al.; Int. J. Mol. Sci. 22, 2277 (2021), Abstract; Full Text
Characterization of excitability and voltage-gated ion channels of neural progenitor cells in rat hippocampus: T. Li, et al.; J. Mol. Neurosci. 35, 289 (2008), Abstract;
A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts: S. Nuding, et al.; J. Microbiol. Methods 65, 335 (2006), Abstract;

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