TSQ is an efficient membrane-permeable fluorescent probe for zinc (II). It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Fluorescence of TSQ is enhanced upon binding Zn (II), but the probe does not demonstrate a shift or change in emission wavelength. TSQ forms a largely insoluble 2:1 (Ligand-Metal) complex with zinc and emits blue light upon excitation at 365 nanometers.
Product Details
| Alternative Name: | N-(6-Methoxy-8-quinolyl)-p-toluenesulfonamide |
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| Formula: | C17H16N2O3S |
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| MW: | 328.4 |
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| CAS: | 109628-27-5 |
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| Excitation maximum: | 344 nm |
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| Emission maximum: | 385 nm |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Light brown to brown solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least one year after receipt when stored as recommended. In solvent: - 80°C, 6 months; -20°C, 1 month. |
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| Handling: | Protect from light. Keep cool and dry. |
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| Technical Info/Product Notes: | This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ: K. Asahina, et al.; Biol. Trace Elem. Res.
200, 1667 (2022),
Abstract;
The Role of Zinc in Axon Formation via the mTORC1 Pathway: S. Choi, et al.; Mol. Neurobiol.
59, 3206 (2022),
Abstract;
Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties: S.J. Allison, et al.; Nat. Commun.
12, 3898 (2021),
Abstract;
Zinc ionophores isolated from Terminalia bellirica fruit rind extract protect against cardiomyocyte hypoxia/reoxygenation injury: V.L. Bodiga, et al.; Bioorg. Med. Chem.
46, 116394 (2021),
Abstract;
Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K-Akt-NF-κB-ERK-dependent pathway: F. Zhou, et al.; J. Neurosci. Res.
89, 1859 (2011),
Abstract;
Histochemical and histofluorescence tracing of chelatable zinc in the developing mouse: Y.B. Nitzan, et al.; J. Histochem. Cytochem.
52, 529 (2004),
Abstract;
Intracellular zinc fluxes associated with apoptosis in growth plate chondrocytes: G.R. Sauer, et al.; J. Cell Biochem.
88, 954 (2003),
Abstract;
