| ENZ-45019-0100 | 100 µg | 445.00 USD |  |
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| Alternative Name: | tRNA (cytosine(38)-C(5))-methyltransferase, PuMet |
| Clone: | 1E12 |
| Host: | Mouse |
| Isotype: | IgG1λ |
| Immunogen: | Recombinant full length TRDMT1 (DNMT2) (aa 1-392) fused to a GST tag. |
| UniProt ID: | O14717 |
| GenBank ID: | AAH47733 |
| Species reactivity: | Human |
| Applications: | ELISA, IF, WB |
| Recommended Dilutions/Conditions: | ELISA (0.25-1µg/ml) Immunofluorescence (5µg/ml) Western Blot (0.5-1µg/ml). Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application |
| Purity Detail: | Protein A purified. |
| Formulation: | Liquid. In 1x PBS, pH 7.2. |
| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | In 2006, TRDMT1 enzyme was shown to methylate position 38 in aspartic acid transfer RNA and does not methylate DNA. To reflect this different function, the name for this methyltransferase was changed from DNMT2 to TRDMT1 (tRNA aspartic acid methyltransferase 1) to better reflect its biological function. TRDMT1 is the first RNA cytosine methyltransferase to be identified in a human. |
| Regulatory Status: | RUO - Research Use Only |
