| Alternative Name: | Hakata antigen, Ficolin-3 |
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| Clone: | FCN334 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Recombinant human H-ficolin. |
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| UniProt ID: | O75636 |
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| Species reactivity: | Human
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| Applications: | ELISA
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| Application Notes: | Detects a band of ~35kDa (monomer) by Western blot. |
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| Purity Detail: | Protein A/G-affinity purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Short Term Storage: | +4°C |
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| Scientific Background: | H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35kDa protein chains associated in triplet subunits, which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region. |
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| Regulatory Status: | RUO - Research Use Only |
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