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APC-PCI complex (human) monoclonal antibody (M36)

BPD-JST-001-38-04 400 µg 1,909.00 USD
BPD-JST-001-38-1 1 ml 3,581.00 USD
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Product Details

Immunogen:Mixture of PCI in complex with PSA (approx. 80%) and PCI cleaved from such a complex (approx. 20%).
UniProt ID:P05154 (human PCI)
Gene/Protein Identifier:5104 (Gene ID)
Species reactivity:Human
Specificity:BPD-JST-001-38 is specific for APC:PCI complex and cleaved PCI but has little reactivity towards native PCI. The dissociation constants (as determined by standard surface plasmon resonance technique) are: Kd= 4x10e-10 M for PCI in complex with APC and 2x10e-10 M for cleaved PCI. The value of Kd for native PCI is too low to measure, i.e. > 10e-5 M.
Applications:ELISA, WB
Purity Detail:Protein A-affinity purified.
Formulation:Liquid. In 0.01 M phosphate buffer, pH 7.4, containing 0.14 M sodium chloride and 15 mM sodium azide.
Shipping:Blue Ice Not Frozen
Short Term Storage:+4°C
Long Term Storage:+4°C
Scientific Background:Activated Protein C (APC), a serine proteinase is inhibited by Protein C inhibitor (PCI). PCI belongs to a group of inhibitors sometimes referred to as serpines (serine proteinase inhibitors), and form 1:1 complexes with APC. PCI plasma concentration is approximately 4 µg/ml. The complex formation between APC and PCI proceeds at a slow rate, which is manifested by a long half-life for APC in plasma, wherein t1/2 is about 20 min. However, the rate of complex formation between APC and PCI is increased by heparin. Upon complex formation with APC, the serpin is cleaved in its so-called bait region, whereby a stable intermediate acyl complex is formed. With time, the intermediate acyl complex dissociates, whereby APC is regenerated and a proteolytically modified, i. e. cleaved, inactive serine proteinase inhibitor is formed.
Regulatory Status:RUO - Research Use Only
APC-PCI complex (human) monoclonal antibody (M36) ELISA
Figure 1. Illustrates the calibration curve of a sandwich assay with BPD-JST-001-38 as the capture antibody and SA001RA as the biotinylated detection antibody.
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APC-PCI complex (human) monoclonal antibody (M36) ELISA

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