Product Specification
| Alternative Name: | Glucagon like peptide 1 |
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| Clone: | 4F3 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Synthetic peptide corresponding to aa 7-36 amide of GLP-1 coupled to carrier. |
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| UniProt ID: | P01275 |
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| Species reactivity: | Mammalian
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| Applications: | ELISA, IHC, WB
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| Purity Detail: | Protein A/G-affinity purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Short Term Storage: | +4°C |
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| Scientific Background: | Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Schematic glucagon-like peptide-1 (GLP-1) showing active, extended and metabolite forms along with select GLP-1 monoclonal antibodies.
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Product Literature References
Identification of serum proteins involved in pancreatic cancer cachexia: K. Felix, et al.; Life Sci.
88, 218 (2011),
Application(s): Immunoaffinity SELDI-TOF MS of human serum samples,
Abstract;
Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell: A.J. Mulherin, et al.; Endocrinology
152, 4610 (2011),
Application(s): Radioimmunoassays with murine GLUTag, human NCI-H716 and rat FRIC cell lysates,
Abstract;
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