| Alternative Name: | Diphtheria toxoid, Corynebacterium diphtheriae |
| |
| Clone: | 17.6B9 |
| |
| Host: | Mouse |
| |
| Isotype: | IgG1κ |
| |
| Immunogen: | Purified Diphtheria toxoid from C. diphtheriae subsp. intermedius Park-Williams no. 8 by formaldehyde inactivation. |
| |
| Species reactivity: | Corynebacterium
|
| |
| Applications: | ELISA
|
| |
| Application Notes: | Detects a band of ~62kDa by Western blot. |
| |
| Purity Detail: | Protein A/G-affinity purified. |
| |
| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
| |
| Shipping: | Blue Ice Not Frozen |
| |
| Short Term Storage: | +4°C |
| |
| Scientific Background: | Corynebacterium diphtheriae is a Gram-positive, non-motile bacterium that can cause serious illness in unvaccinated humans. C. diphteriae infects the epithelial cells of the upper respiratory tract, which then secrete a potent toxin absorbed and disseminated through lymph channels and blood to the susceptible tissues of the body. The toxin is a single protein chain of 62kDa which is "nicked" at proteolytic processing sites to produce an A chain of 21kDa and a B chain of 40kDa, held together by a disulfide bridge. The A-chain carries the ADP-ribosylation enzymatic activity responsible for the toxic action. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
