| Alternative Name: | FN |
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| Clone: | A17 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Lysed bovine corneal endothelial cells and extracellular matrix. |
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| UniProt ID: | P07589 |
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| GenBank ID: | 280794 |
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| Source: | From culture supernatant. |
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| Species reactivity: | Human
Bovine, Chicken
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| Specificity: | Epitope is located in the 120kD cell binding fragment. |
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| Crossreactivity: | There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, elastin, collagen, laminin). |
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| Applications: | ELISA, IHC (FS), IHC (PS), IP, WB
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| Application Notes: | The antibody inhibits integrin-mediated cell adhesion to the cell binding domain of fibronectin. |
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| Purity Detail: | Protein A/G-purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Fibronectin is an adhesive glycoprotein with a molecular mass of 440kDa which appears important in the formation of a provisional matrix to promote cell adhesion and migration during wound healing. Its age-dependent increase in plasma and tissues may accompany a proteolytic breakdown by a number of neutral proteases in pathological states, especially in tumor growth. Several of its proteolytic breakdown products exhibit unexpected and primarily harmful biological activities. |
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| Regulatory Status: | RUO - Research Use Only |
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