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Fibronectin monoclonal antibody (A17)

 
BPD-CSI-005-17-04 400 µg 1,100.00 USD
 
BPD-CSI-005-17-1 1 mg 2,585.00 USD
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Product Details

Alternative Name:FN
 
Clone:A17
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Lysed bovine corneal endothelial cells and extracellular matrix.
 
UniProt ID:P07589
 
GenBank ID:280794
 
Source:From culture supernatant.
 
Species reactivity:Human
Bovine, Chicken
 
Specificity:Epitope is located in the 120kD cell binding fragment.
 
Crossreactivity:There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, elastin, collagen, laminin).
 
Applications:ELISA, IHC (FS), IHC (PS), IP, WB
 
Application Notes:The antibody inhibits integrin-mediated cell adhesion to the cell binding domain of fibronectin.
 
Purity Detail:Protein A/G-purified.
 
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Fibronectin is an adhesive glycoprotein with a molecular mass of 440kDa which appears important in the formation of a provisional matrix to promote cell adhesion and migration during wound healing. Its age-dependent increase in plasma and tissues may accompany a proteolytic breakdown by a number of neutral proteases in pathological states, especially in tumor growth. Several of its proteolytic breakdown products exhibit unexpected and primarily harmful biological activities.
 
Regulatory Status:RUO - Research Use Only
 

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