| Alternative Name: | Serum spreading factor, S-protein |
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| Clone: | A18 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Lysed bovine corneal endothelial cells and extracellular matrix. |
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| GenBank ID: | 507525 |
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| Source: | From culture supernatant. |
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| Species reactivity: | Bovine, Horse, Rabbit
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| Specificity: | The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation. |
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| Crossreactivity: | Does not cross-react with human or sheep. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). |
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| Applications: | ELISA, IHC (FS), IHC (PS)
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| Purity Detail: | Protein A/G-purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Vitronectin is a plasma glycoprotein that circulates in the blood as a mixture of both 75kDa and 65kDa forms. Vitronectin is a major cell adhesive glycoprotein, and a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins, and often participates in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin, which is recognized by its integrin receptor. |
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| Regulatory Status: | RUO - Research Use Only |
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