| Alternative Name: | γENaC |
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| Clone: | 11-35-1 |
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| Host: | Mouse |
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| Isotype: | IgG1κ |
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| Immunogen: | Synthetic peptide seguence: VGGSIIHKAC |
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| UniProt ID: | P51170 |
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| Source: | From culture supernatant. |
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| Species reactivity: | Human
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| Specificity: | Specific for the neoepitope generated after proteolytic cleavage of human γENaC and recognizes the C-terminal fragment. |
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| Applications: | ELISA, IF, IHC (FS), IHC (PS), WB
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| Purity Detail: | Protein A/G-purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | The epithelial sodium channel (ENaC) of the kidney is necessary for extracellular volume homeostasis and normal arterial BP. Activity of ENaC is enhanced by proteolytic cleavage of the γ-subunit. In the γ-subunit, putative cleavage sites for prostasin, kallikrein (similar site as prostasin), elastase, and plasmin exist. Prostasin is a glycosylphosphatidylinositol anchored apical serine protease expressed in the collecting duct that activates γENaC at a site close to but in the C-terminal direction to the furin cleavage with putative release of a 43-residue inhibitory tract. |
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| Regulatory Status: | RUO - Research Use Only |
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