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Ghrelin monoclonal antibody (121) (biotin conjugate)

 
BPD-ABS-052-121B-015 150 µg 1,870.00 USD
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Product Details

Clone:121
 
Host:Mouse
 
Isotype:IgG2bκ
 
Immunogen:Synthetic peptide corresponding to aa 14-28 of human ghrelin.
 
UniProt ID:Q9UBU3
 
GenBank ID:51738
 
Species reactivity:Human, Mouse, Rat
Cat, Dog
 
Applications:ELISA
 
Purity Detail:Protein A purified.
 
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.14M sodium chloride and 15mM sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing; Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3; this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food may reflect those of active ghrelin.
 
Regulatory Status:RUO - Research Use Only
 

General Literature References

Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates: K.E. Foster-Schubert, et al.; J. Clin. Endocrinol. Metab. 93, 1971 (2008), Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review), Abstract;
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor: M. Kojima, et al.; Trends Endocrinol. Metab. 12, 118 (2001), Abstract;

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