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United States 

Ghrelin (human) monoclonal antibody (45)

BPD-ABS-050-45-04 400 µg 1,966.00 USD
BPD-ABS-050-45-1 1 mg 3,837.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to the sequence of human human Ser3-octanoyl ghrelin-28
UniProt ID:Q9UBU3
Species reactivity:Human
Applications:ELISA, WB
Purity Detail:Protein A affinity purified.
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Ghrelin is an orexigenic (food intake stimulating) 27 or 28 amino-acid gut-brain peptide hormone produced by endocrine cells in the stomach, pancreatic islets and certain hypothalamic neurons. Two forms are produced by alternative mRNA splicing; Gln13 or 14 is missing from the second form. "Active" ghrelin is acylated (octanoylated) at Ser3; this form stimulates growth hormone secretion via GHS receptors and increases appetite. The des-acyl form does not have these effects but may have other actions. Plasma responses of total ghrelin to food may reflect those of active ghrelin.
Regulatory Status:RUO - Research Use Only

General Literature References

Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates: K.E. Foster-Schubert, et al.; J. Clin. Endocrinol. Metab. 93, 1971 (2008), Abstract;
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review), Abstract;
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor: M. Kojima, et al.; Trends Endocrinol. Metab. 12, 118 (2001), Abstract;