| Alternative Name: | PHM |
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| Clone: | 3 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Synthetic human peptide histidine-methionine. |
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| UniProt ID: | P01282 |
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| GenBank ID: | 7432 |
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| Source: | From culture supernatant. |
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| Species reactivity: | Human
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| Crossreactivity: | Cross-reacts with PACAP (approximately 12%; incomplete, non-parallel inhibition). ABS 020-03 does not cross-react with GLP-1, GLP-2, VIP or glucagon. |
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| Applications: | ELISA, IHC
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| Purity Detail: | Protein A/G-purified. |
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| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Human peptide histidine-methionine (PHM) is a 27-amino-acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations, the peptides reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome. |
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| Regulatory Status: | RUO - Research Use Only |
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