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Gelsolin (human) monoclonal antibody (20)

 
BPD-ABS-017-20-04 400 µg 1,485.00 USD
 
BPD-ABS-017-20-1 1 mg 3,374.00 USD
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Product Details

Clone:20
 
Host:Mouse
 
Isotype:IgG1κ
 
Immunogen:Purified gelsolin from human plasma.
 
UniProt ID:P06396
 
GenBank ID:2934
 
Source:From culture supernatant.
 
Species reactivity:Human
 
Applications:ELISA, IF, IHC, WB
 
Purity Detail:Protein A/G-purified.
 
Formulation:Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Gelsolin participates in the extracellular actin scavenger system, binding actin and disaggregating filamentous actin released from dying cells. Actin monomers are then transferred to Gc-globulin. The plasma concentration of gelsolin is reduced in conditions of major actin release, such as acute liver failure, major trauma and rhabdomyolysis, where multi-organ failure is a risk. It has been suggested that gelsolin, like Gc-globulin, can be a prognostic factor in these conditions.
 
Regulatory Status:RUO - Research Use Only
 
BPD-ABS-017-20 IF
Figure 1. Immunofluorescent staining of human cell line U-251 MG with BPD-ABS-017-20 shows positivity in actin filaments. Antibody dilution: 1:2000
BPD-ABS-017-20 IHC
Figure 2. Immunohistochemical staining of human kidney with ABS 017-20 shows cytoplasmic and membranous positivity in both renal tubules and glomeruli. Antibody dilution: 1:6000
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BPD-ABS-017-20 IF BPD-ABS-017-20 IHC

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