| Alternative Name: | PAPP-A, Pappalysin-1, Insulin-like growth factor binding protein-4 protease |
| |
| Clone: | PAPP A 1-24 |
| |
| Host: | Mouse |
| |
| Isotype: | IgG1κ |
| |
| Immunogen: | Purified human PAPP-A. |
| |
| UniProt ID: | Q13219 |
| |
| GenBank ID: | 5069 |
| |
| Source: | From culture supernatant. |
| |
| Species reactivity: | Human
|
| |
| Specificity: | Specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. |
| |
| Applications: | ELISA, IHC, WB
|
| |
| Purity Detail: | Protein A/G-purified. |
| |
| Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.5M sodium chloride and 15mM sodium azide. |
| |
| Shipping: | Blue Ice Not Frozen |
| |
| Long Term Storage: | +4°C |
| |
| Scientific Background: | Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21). |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
