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Wnt pathway activator
BML-WN117-0005 5 mg 159.00 USD
BML-WN117-0025 25 mg 665.00 USD
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Synergizers with Wnt3a to activate the Wnt/β-catenin pathway. Binds and inhibits GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), thus activating ARF. It has also been suggested that a possible mechanism by which QS11 synergizes Wnt is through ARFGAP1 inhibition leading to increased β-catenin translocation via ARF activation.

Product Details

Alternative Name:(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-ylmethyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C.
Handling:Solutions can be stored at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-Wn117 Structure
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BML-Wn117 Structure

Product Literature References

Small-molecule synergist of the Wnt/ß-catenin signaling pathway: Q. Zhang et al.; Proc. Natl. Acad. Sci. USA 104, 7444 (2007), Abstract; Full Text

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