IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. Upregulates expression of Oct4 and Sox2 transcription factors.
Product Details
| Alternative Name: | 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide |
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| Formula: | C21H22N4O2 |
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| MW: | 362.4 |
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| CAS: | 331001-62-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or in 100% ethanol (10mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Wnt/b-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotnncy: T. Miyabayashi, et al.; Proc. Natl. Acad. Sci. USA
104, 5668 (2007),
Abstract;
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