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IQ-1

Disrupts Wnt signaling
 
BML-WN115-0005 5 mg 107.00 USD
 
BML-WN115-0025 25 mg 472.00 USD
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IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. Upregulates expression of Oct4 and Sox2 transcription factors.

Product Specification

Alternative Name:2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide
 
Formula:C21H22N4O2
 
MW:362.4
 
CAS:331001-62-8
 
Purity:≥98% (TLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (25mg/ml) or in 100% ethanol (10mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
BML-WN115 Structure
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BML-WN115 Structure

Product Literature References

Wnt/b-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotnncy: T. Miyabayashi, et al.; Proc. Natl. Acad. Sci. USA 104, 5668 (2007), Abstract; Full Text

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