Inhibits Wnt signaling via blocking transcription at the β-catenin level independent of CBP or p300. Inhibited growth in several cancer cell lines (HT29, HCT116, SW480, and SNU475). CCT036447 was also active in vivo where it blocked development of zebrafish and Xenopus embryos and the expression of Wnt target genes.
Product Details
| Alternative Name: | N-((4-Chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine |
| |
| Formula: | C21H18ClN3 |
| |
| MW: | 347.8 |
| |
| CAS: | 305372-78-5 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | Yellow solid. |
| |
| Solubility: | Soluble in DMSO (25mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
| |
| Handling: | Solutions can be stored at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription : K. Ewan et al. ; Cancer Res.
70, 5963 (2010),
Abstract;
Full Text
