Cell-permeable compound that disrupts Wnt signaling by binding to the PDZ domain of dishevelled (Kd=10.6 µM). Blocked Wnt3a-induced transcription activity and was able to supress the Wnt pathway-dependent growth of prostate cancer PC-3 cells (IC50=12.5 µM). BML-286 was also capable of supressing Wnt signaling in vivo (Xenopus embryo and mouse hyaloids vessel system).
Product Details
| Alternative Name: | 3289-8625 |
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| Formula: | C22H18N2O4 |
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| MW: | 374.4 |
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| CAS: | 294891-81-9 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white to light-orange. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Discovery and Characterization of a Small Molecule Inhibitor of the PDZ domain of Dishevelled: D. Grandy, et al.; J. Biol. Chem.
284, 16256 (2009),
Abstract;
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