Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. FH535 was toxic (LC50=5 to 15µM) to 10 of 12 carcinoma cell lines tested. A unique tool to study the relationship between Wnt and PPAR signaling pathways.
Product Specification
| Alternative Name: | N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide |
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| Formula: | C13H10Cl2N2O4S |
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| MW: | 361.2 |
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| CAS: | 108409-83-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (20mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cell-based assay for low and high scale screening of the Wnt/β-catenin signaling modulators: M. Mazur, et al.; Anal. Biochem.
475, 56 (2015),
Application(s): Cell Culture,
Abstract;
A small-molecule inhibitor of Tcf/ß-catenin signaling down-regulates PPARτ and PPARδ activities : S. Handeli & J. Simon; Mol. Cancer Ther.
7, 521 (2008),
Abstract;
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