Selective inhibitor(EC50=6.97µM) of Secreted Frizzled Related Protein-1 (sFRP-1). Treatment of mouse calvaria (ex vivo) resulted in a 50% increase in total bone area compared to control with an increased number of osteoblasts. A useful tool for studying the Wnt signaling pathway.
Product Details
| Alternative Name: | N-[2,(3,4-dimethoxyphenyl)ethyl]-2-ethyl-5-(phenylsulfonul)benzenesulfonamide |
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| Formula: | C24H27NO6S2 |
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| MW: | 489.6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (40mg/ml) or in 100% ethanol (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Identification of Diarylsulfone Sulfonamides as Secreted Frizzled Related Protein-1 (sFRP-1) Inhibitors: A. Gopalsamy, et al.; J. Med. Chem.
51, 7670 (2008),
Abstract;
