Wnt agonist that activates Wnt signaling in cellular assays and a Xenopus model. Induces β-catenin and TCF-dependent transcriptional activity in a dose-dependent manner (EC50=0.7μM). Wnt activation occured in a GSK-3β independent manner.
Product Details
| Alternative Name: | 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine |
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| Formula: | C19H18N4O3 |
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| MW: | 350.4 |
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| CAS: | 853220-52-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or in 100% ethanol (25 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A Small-Molecule Agonist of the Wnt Signaling Pathway: J. Liu, et al.; Angew. Chem. Int. Ed.
44, 1987 (2005),
Abstract;
