Replaces Prod. #: ENZ-CHM144
GSK-3β inhibitor (IC50=53nM (enzymatic), 3.8µM (cellular)). The compound significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.
Product Details
| Alternative Name: | 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
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| Formula: | C22H20FN3O2 |
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| MW: | 377.4 |
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| CAS: | 1129669-05-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or in 100% ethanol (5 mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel indolylmaleimide acts as GSK3ß inhibitor in human neural progenitor cells: A.-C. Schmole, et al.; Bioorg. Med. Chem.
18, 6785 (2010),
Abstract;
