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IM-12

 
BML-WN102-0005 5 mg 103.00 USD
 
BML-WN102-0025 25 mg 406.00 USD
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Replaces Prod. #: ENZ-CHM144

GSK-3β inhibitor (IC50=53nM (enzymatic), 3.8µM (cellular)). The compound significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.

Product Details

Alternative Name:3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
 
Formula:C22H20FN3O2
 
MW:377.4
 
CAS:1129669-05-1
 
Purity:≥98% (HPLC)
 
Appearance:Orange solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or in 100% ethanol (5 mg/ml).
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Use/Stability:Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
BML-WN102 Structure
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BML-WN102 Structure

Product Literature References

Novel indolylmaleimide acts as GSK3ß inhibitor in human neural progenitor cells: A.-C. Schmole, et al.; Bioorg. Med. Chem. 18, 6785 (2010), Abstract;

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