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PARP5a inhibitor
BML-WN100-0005 5 mg 72.00 USD
BML-WN100-0025 25 mg 287.00 USD
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Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Product Details

Alternative Name:3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (20 mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Handling:Solutions can be stored at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-WN100 Structure
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BML-WN100 Structure

Product Literature References

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling: S. Huang, et al.; Nature 461, 614 (2009), Abstract;

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