Replaces Prod. #: ALX-340-060
Unnatural fatty acid-neurotransmitter conjugate. Potent TRPV1 antagonist (IC50=40nM). Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.6mM). Enhances levels of anandamide and 2-AG in vivo. Displays analgesic activity in both acute and chronic peripheral pain models but shows little efficacy in an inflammatory bowel disease model.
Product Details
| Formula: | C30H42N2O2 |
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| MW: | 462.7 |
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| CAS: | 187947-37-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow oil. |
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| Solubility: | Soluble in DMSO (>25mg/ml), 100% ethanol (15mg/ml) or dimethyl formamide (30mg/ml); also soluble in PBS, pH 7.2 (290µg/ml). |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from air. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors: S. Maione, et al.; Br. J. Pharmacol.
150, 766 (2007),
Abstract;
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation: G. D'Argenio, et al.; FASEB J.
20, 568 (2006),
Abstract;
Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels: E. de Lago, et al.; Biochem. Pharmacol.
70, 446 (2005),
Abstract;
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase: T. Bisogno, et al.; BBRC
248, 515 (1998),
Abstract;
