Product Details
| Alternative Name: | Protein inhibitor of activated STAT protein 1, SUMO E3 ligase PIAS1 |
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| MW: | ~70 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | O75925 |
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| Formulation: | Liquid. In 50mM Na-phosphate, pH 7.5, 200mM NaCl. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Purity Detail: | Purified by glutathione affinity chromatography. |
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| Biological Activity: | Exhibits SUMO modification activity in vitro. |
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| Application Notes: | For use in SUMO modification reactions and SUMOylation pathway studies. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | PIAS1 is a SUMO E3 ligase with specificity for a range of different substrates including p53, Hdm2, transcription factors, androgen receptors and co-repressor proteins. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease: C.C. Tao, et al.; Cell Death Differ.
24, 597 (2017),
Abstract;
Full Text
Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2: W.L. Hsu, et al.; BMC Biol.
15, 112 (2017),
Application(s): In vitro SUMOylation assay,
Abstract;
Full Text
MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome: D.J. Tai, et al.; Nat. Commun.
7, 10552 (2016),
Abstract;
Full Text
Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors: A.M. Jaeger, et al.; Nat. Struct. Mol. Biol.
23, 147 (2016),
Application(s): Used in in vitro SUMOylation assays,
Abstract;
