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PIAS1 (human), (recombinant) (GST-tag)

BML-UW9960-0025 25 µg Inquire for pricing
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Product Details

Alternative Name:Protein inhibitor of activated STAT protein 1, SUMO E3 ligase PIAS1
MW:~70 kDa
Source:Produced in E. coli.
UniProt ID:O75925
Formulation:Liquid. In 50mM Na-phosphate, pH 7.5, 200mM NaCl.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by glutathione affinity chromatography.
Biological Activity:Exhibits SUMO modification activity in vitro.
Application Notes:For use in SUMO modification reactions and SUMOylation pathway studies.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:PIAS1 is a SUMO E3 ligase with specificity for a range of different substrates including p53, Hdm2, transcription factors, androgen receptors and co-repressor proteins.
Regulatory Status:RUO - Research Use Only

Product Literature References

Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease: C.C. Tao, et al.; Cell Death Differ. 24, 597 (2017), Abstract; Full Text
Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2: W.L. Hsu, et al.; BMC Biol. 15, 112 (2017), Application(s): In vitro SUMOylation assay, Abstract; Full Text
MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome: D.J. Tai, et al.; Nat. Commun. 7, 10552 (2016), Abstract; Full Text
Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors: A.M. Jaeger, et al.; Nat. Struct. Mol. Biol. 23, 147 (2016), Application(s): Used in in vitro SUMOylation assays, Abstract;

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